DuoBioX® Explore is a mammalian and microbial cell culture bioreactor system with aninnovative design, outstanding performance, comprehensive functions, and user-friendly operation. Users only need one computer to control 1 to 8 glass tanks to run independently or inparallel.
Advantages
Multiple tank specification options, including 500 mL, 3 L, 7 L and 15 L.
Satellite design provides great flexibility for system expansion, quickly realize multi-connection or parallel control of 1 to 8 tanks, DuoBioX® Explore system can easily realize parameter setting, process program calling, data backup, and can compare and analyze the trend of different batches under the same interface.
Powerful software functions can realize full control based on feedback, time, conditions and script recipes, which can meet the strict process requirements.
The operating system developed based on the WinCC industrial-grade architecture meets the requirements of GMP and 21 CFR Part 11, and can be used in pharmaceutical and medical industries.
Complete network communication interface, docking with SCADA to realize data collection and remote monitoring.
In addition to basic DO, pH, temperature, liquid level, stirring control unit, the system can provide up to three gas supply channels, including overlay gas supply, macro-sparge bottom gas supply and micro-sparge bottom gas supply, allowing users to design flexible air supply strategy, and easily support high-density perfusion cell culture process; the optimized exhaust gas cooling device can effectively prevent clogging, and is compatible with fermentation/high-density cell culture.
The controller is designed with 2 additional input ports, which can be connected to sensors, such as sensors of cell density, CO2 and weighing, and additional signals can be integrated in control loop.
Model | Explore 500 mL | Explore 3 L | Explore 7 L | Explore 15 L |
Function | Mammalian cell culture (compatible with microorganisms), control up to 8 tanks | |||
Tank | ||||
Working volume | 400 mL | 2 L | 5 L | 10 L |
Max working volume | 500 mL | 3.1 L | 6.8 L | 15 L |
Min working volume | 100 mL | 0.6 L | 1.5 L | 3.2 L |
Aspect ratio | 2:1 | 1.9:1 | 2.2:1 | |
Np value | 1.5 | |||
Blade | 3 pitched blades 45° | |||
Blade diameter | 35 mm | 45 mm | 60 mm | 75 mm |
Gas supply tube diameter | 4 mm | 6 mm | 8 mm | 8 mm |
Macro-sparge diameter | 0.5 mm | 1 mm | ||
Macro-sparge number | 3 | 5 | 7 | 9 |
Micro-sparge pore size | none | 5 μm for optional | ||
Controller | ||||
pH sensor | Inpro3100i/SG/ 225 | Inpro3100i/SG/ 325 | Inpro3100i/SG/ 425 | |
DO sensor | 243666-142/225(optical)H2 | 243666-142/325 (optical)H2 | 243666-142/425 (optical)H2 | |
CO2 sensor | Optional | |||
Overlay | Rotor flow meter (MFC for optional) | |||
MFC-Air | 0~0.1 L | 0~0.5 L | 0~1 L | 0~3 L |
MFC-O2 | 0~0.1 L | 0~0.5 L | 0~1 L | 0~3 L |
MFC-CO2 | 0~0.1 L | 0~0.1 L | 0~0.5 L | 0~1 L |
MFC-N2 | Optional | |||
MFC-O2 micro sparge | 0~0.1 for optional | 0~0.5 for optional | 0~1 for optional | |
Built-in peristaltic pump | 4xWaston Malow 114D variable speed pump | |||
Temperature control | Electric heating base 100w Cold water solenoid valve | |||
Exhaust gas cooling | none | Semiconductor or water cooling | ||
Weighting | Optional | |||
Control software (need to be installed on user's computer) | ||||
21 CFR Part 11 | Yes | |||
Data record | Yes | |||
User authorization management | 4 levels | |||
Utilities requirements | ||||
Gas source | Air、O2、CO2 | |||
Gas source pressure | 0.2-0.3 MPa | |||
Control cabinet power supply | 220 v 50 Hz | |||
Power socket | 10A three-hole | |||
Cabinet dimension | Length*width*height 554*188*404 mm | |||
Single tank external dimensions | Height*diameter 357*100 mm | Height*diameter 430*210 mm | Height*diameter 510*250 mm | Height*diameter 690*280 mm |
Cabinet net weight | 45 kg | |||
Tank net weight | 2 kg | 8 kg | 11 kg | 15 kg |
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